August 14, ; Accepted date: September 13, ; Published date: J Clinic Toxicol 2: This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Visit for more related articles at Paracetamol high yahoo dating of Clinical Toxicology. The Effect of Paracetamol mechanism by which it works, metabolism, recommended doses, toxic dosage are discussed with study reports in this paper. Paracetamol shows some life threatening effects like Liver damage which in turn leads to live failure and death.
Though it reduces fever and pain, it is found highly toxic. The mechanism by which Paracetamol reduces fever and pain is still not known. On metabolism, Paracetamol is converted to a metabolite which is very toxic to liver cells. In our day to day life we are using so many drugs as medicines. We are consuming such medicines unknowing their nature, properties, mechanism of action, toxicity, etc.
One among them is Paracetamol which we often use to get relief from fever, headache and certain pains such as muscle aches, arthritis, backache, toothache and cold. But Paracetamol shows some strange and life threatening effects i. Paracetamol or acetaminophen is an active metabolite of phenacetin. Unlike aspirin, Paracetamol is not a very effective anti-inflammatory agent. It is well tolerated, lacks many of the side Paracetamol high yahoo dating of aspirin and is available over-the-counter, so it is commonly used for the relief of fever, headache and other minor aches and pains.
Paracetamol is also useful in the management of more severe pains, where it allows lower dosages of additional Non-Steroidal Anti-Inflammatory Drugs NSAIDs or opioid analgesics to be used, thereby minimizing overall side-effects. It is a major ingredient in numerous cold and flu medications, including Tylenol and Panadol, among others. It is considered safe for human use at recommended doses; however acute overdose can cause fatal liver damage, often heightened with use of alcohol and the number of accidental self-poisoning and suicides has grown in recent years.
Its history says that when Cinchona tree became scarce in the s, people began to look for alternatives. Two alternative antipyretic agents were developed in s; Acetanilide in and Phenacetin in Harmon Northrop Morse first synthesized Paracetamol via the reduction of P-nitrophenol with Tin in glacial acetic acid in ; "Paracetamol high yahoo dating," Paracetamol was not used in medical treatment for another 15 years. In, Paracetamol was discovered in the urine of individuals that had taken Phenacetin and Paracetamol high yahoo dating concentrated into white crystalline compound with a bitter taste.
InParacetamol was found to be a metabolite of acetanilide. This discovery was largely ignored at that time. InBrodie and Axelrod determined that the analgesic effect of acetanilide was due to its active metabolite Paracetamol. Paracetamol is a para-aminophenol Paracetamol high yahoo dating that exhibits analgesic and anti-pyretic activity. The mechanism of action is dependent on the inhibition of prostaglandin synthesis in the Central Nervous System CNS and peripherally blocks pain impulse generation [ 1 ].
It does not possess anti-inflammatory activity. provides relief from mild to moderate pain and fever.
Binding to the plasma proteins is minimal at therapeutic concentrations [ 2 ]. High dose-usage greater than 2, mg per day of Paracetamol increases the risk of upper gastrointestinal complications like stomach bleeding.
A study in on long term side effects of Paracetamol tablets in children found administering Paracetamol for fever in the first year of life was linked with an increase in the incidence of asthmatic symptoms at years. It also stated that use of Paracetamol both in the first year of life and in children aged years was associated with an increased incidence of rhinoconjunctivitis and eczema [ 3 ].