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Kyeo-Woon Jung MATERIAL AND METHODS...

Cumulative propofol dose at each sampling point during infusion of microemulsion and LCT and the plasma concentrations of propofol over time.

A Cumulative propofol dose at 10, 30, and 60 min after the start of propofol formulation infusion and at the end of infusion. B Plasma propofol concentrations at LOC, 10, 30, and 60 min after the start of propofol formulation infusion.

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C Plasma propofol concentrations at 0, 1, 6, 12, and 24 h after each propofol formulation was discontinued. Effectiveness, safety, and pharmacokinetic and pharmacodynamic characteristics of microemulsion propofol in patients undergoing elective surgery under total intravenous anaesthesia.

At LOC, there were no significant differences in the plasma concentrations of microemulsion Plasma propofol concentrations during infusion except at LOC and up to 1 h after dis- continuation of propofol infusion were ROO The cumulative propofol dose of microemulsion propo- fol at each Kyeo woon wife sexual dysfunction point was not significantly different from that of LCT propofol Fig.

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Plasma propofol concentrations during infusion except at LOC and up to 1 h after dis- continuation of propofol infusion were consistently lower in patients receiving microemulsion propofol Fig. The final pharmacokinetic models resulted in an improvement in the objective function values Novel propofol derivatives and implications for anesthesia practice.

SMOFlipid emulsion was chosen for lipid infusion due to its improved composition by containing other oils than soya-bean and lower incidence of side effects multi-organ damage compared with other vehicles Koller et al.

Notwithstanding, the clinical and scientific popularity achieved with parenteral nutrition or propofol emulsions challenged the discovery of new lipid-based formulations Knibbe et al.

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