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Describe the factors that promote sexual differentiation in utero


During embryonic development there is a sexually indifferent stage in which the embryo has the potential to develop either male or female structures. Internally, adjacent to each developing gonad, are two primitive ducts that can give rise to either the male or the female reproductive tracts.

The Wolffian mesonephric ducts are more medial. Sexual differentiation begins with sexual determination , which depends upon the sex chromosomes, X and Y. Sexual determination involves the specification of the gonads as either testes or ovaries. The protein produced by SRY activates a gene network that directs the gonads to develop as testes. In the absence of a Y chromosome and SRY, the gonads develop as ovaries. Once the gonad begins to develop as a testis, the two support cells in the testis differentiate and begin to generate important regulatory molecules that direct sexual differentiation.

Exploring the Biological Contributions to Merciful Health: National Academies Press US ; Sex differences of importance to health and hominid disease occur throughout the get-up-and-go span, although the specific show of these differences varies at different stages of life. Some differences originate in events occurring in the intrauterine environment, where developmental processes differentially organize tissues for later activation in the male or female.

In the prenatal period, sex determination and differentiation occur in a series of sequential processes governed via genetic and environmental factors. Throughout the pubertal period, behavioral and hormonal changes manifest the less important sexual characteristics that reinforce the sexual identity of the discrete through adolescence and into adulthood.

Hormonal events occurring in teens lay a framework for biological differences that persist through lifetime and that contribute to fickle onset and progression of illness in males and females. It is important to study relations differences at all stages of the life cycle, relying on animal models of disease and including sex as a unstable in basic and clinical experiment with designs.

All human individuals—whether they have an XX, an XY, or an atypical sex chromosome combination—begin development from the look-alike starting point. During early circumstance the gonads of the fetus remain undifferentiated; that is, all fetal genitalia are the changeless and are phenotypically female.

After approximately 6 to 7 weeks of gestation, however, the phraseology of a gene on the Y chromosome induces changes that result in the development of the testes. Thus, this gene is singularly important in inducing testis development. The production of testosterone at about 9 weeks of gestation results in the development of the reproductive lot and the masculinization the universal development of male sex characteristics of the brain and genitalia.

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Fetal Development and Sexual Differentiation

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  • physiologic and genetic aspects of the fetal sexual differentiation of the gonads, the internal Factors involved in early gonadal ridge development. . described as a regulator of steroid hydroxylases, is an orphan nuclear . promote phosphorylation and activation of the p38 kinase (Table 3), which in turn.
  • Sexual differentiation in humans is the process of development of sex differences in humans. In humans, biological sex is determined by five factors present at birth: the presence or absence of a Y chromosome, the type of gonads, the . MIS blocks the development of paramesonephric ducts, promoting their regression.
  • Sexual differentiation in humans - Wikipedia
  • Sex Begins in the Womb - Exploring the Biological Contributions to Human Health - NCBI Bookshelf

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Describe the factors that promote sexual differentiation in utero
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Exploring the Biological Contributions to Human Health: Does Sex Matter?

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